During DNA replication in the germ line of mice, the oxidized base 8-oxoguanine (8-oxoG) causes spontaneous and heritable G to T transversion mutations. These mutations occur in different stages of the germ cell lineage and are distributed throughout the chromosomes.

What is an example of transversion mutation?

Transversion substitution refers to a purine being replaced by a pyrimidine, or vice versa; for example, cytosine, a pyrimidine, is replaced by adenine, a purine. Mutations can also be the result of the addition of a base, known as an insertion, or the removal of a base, also known as deletion.

Is Sickle Cell Anemia A transversion mutation?

Sickle cell anemia is caused by a transversion: T is substituted for A in the gene for a hemoglobin subunit. This mutation has arisen numerous times in human evolution. It causes a single amino acid change, from glutamic acid to valine, in the β subunit of hemoglobin.