Disulfiram works by blocking the breakdown of alcohol in the body. This leads to buildup of a toxic alcohol-related compound that can cause people who drink alcohol while taking this medication to become very sick. This reaction helps encourage people to avoid alcohol while taking the medication.

What will happen if you drink alcohol while taking Antabuse?

Using alcohol, even a small amount, while taking this medication can lead to a reaction that may include flushing, throbbing headache, breathing problems (e.g., shortness of breath, fast breathing), nausea, vomiting, dizziness, extreme tiredness, fainting, fast/irregular heartbeat, or blurred vision.

What does disulfiram do to the brain?

How Does Disulfiram Work? Unlike other medications used during alcoholism treatment, disulfiram does not affect the brain's receptors. Instead, it works by altering how your body breaks down and eliminates alcohol from your system.