To offset problems, your doctor can give you a shot of RhoGAM — generic: Rho(D) immune globulin — at about 28 weeks of pregnancy and whenever your blood may mix with your baby's, like during prenatal tests or delivery.

When should RhoGAM be given?

When should I get the RhoGAM shot? If your doctor determines that you may have Rh incompatibility, you'll get a shot of RhoGAM when you're between 26 and 28 weeks pregnant and then again within 72 hours after delivery to ensure that future pregnancies are as safe as the first.

What blood type requires a RhoGAM shot?

You should get a RhoGAM shot within 72 hours of the possible exposure to Rh-positive blood for the shot to work best. How safe is RhoGAM? RhoGAM is very safe. It is recommended for all pregnant women with Rh-negative blood type and has been used for about 50 years.