Typically, patients are advised to take their levothyroxine first thing in the morning, at least 30 minutes but preferably an hour before eating, on an empty stomach and with only water. The goal is to achieve consistency in taking the medication to avoid fluctuations in thyroid levels and variable control of symptoms.

Is it better to take levothyroxine in the morning or at night?

There is consensus that levothyroxine should be taken in the morning on an empty stomach. A pilot study showed that levothyroxine intake at bedtime significantly decreased thyrotropin levels and increased free thyroxine and total triiodothyronine levels.

How long after eating can I take levothyroxine at night?

When patients are going to take their levothyroxine at bedtime, the following instructions should be provided: Take levothyroxine as close to 4 hours after the last meal/snack, as possible.