Unfortunately, they don't just kill pain. They also disrupt the normal balance of the beneficial bacteria living in your gut. Proton Pump Inhibitors (PPIs) – These acid blockers—used to treat indigestion, peptic ulcers and acid reflux—are also known to reduce the diversity of gut bacteria.

Should I take probiotics with PPIs?

The probiotics supplements may not influence the acid-suppression efficacy because esomeprazole is the most effective and long-lasting antacid PPI[24]. Acid suppression with PPIs has been suggested to be a precursor to the development of SIBO.

Do PPIs affect gut bacteria?

PPI use is associated with decreased bacterial richness and profound changes in the gut microbiome: 20% of the identified bacteria in this study showed significant deviation. Oral bacteria and potential pathogenic bacteria are increased in the gut microbiota of PPI users.