One drug that is commonly used for topical chemotherapy to treat squamous cell carcinoma is fluorouracil (5-FU). This drug is: Available in cream or lotion form. Applied by a patient at home over the course of approximately three to six weeks.

Is fluorouracil effective against squamous cell carcinoma?

Daily application of topical fluorouracil for 4 weeks reduced the risk of developing squamous cell cancer (SCC) requiring surgery by 75% in a population of high-risk older adults.

What cream is used for squamous cell carcinoma?

A cream called imiquimod is a type of immunotherapy that causes the body's immune system to destroy cancer cells. It is used to treat sunspots, superficial BCCs and squamous cell carcinoma in situ (Bowen's disease).