Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, with no further increments expected beyond. Changes in erections/ejaculations may require up to 6 months. Effects on quality of life manifest within 3–4 weeks, but maximum benefits take longer.

When is the best time of day to inject testosterone?

Serum testosterone concentrations are diurnal. In young men, the concentrations are highest in the morning. Older men tend to have similar, but blunted, patterns. Clinicians should draw serum testosterone levels between 8:00 am and 11:00 am.

How long does it take for TRT injection to work?

You can expect to notice an improvement in mood and reduced depression about six weeks after beginning TRT injections. Patients who want increased stamina and more energy will see results emerge after 3 months.