Collagen in the subendothelial matrix and tissue factor facilitate the maintenance of a closed circulatory system. When the vessel wall is breached or the endothelium is disrupted, collagen and tissue factor become exposed to the flowing blood, thereby initiating formation of a thrombus (Figure 2).
How does a thrombus develop?
Doctors describe the development of a thrombus as thrombosis. A thrombus is most likely to occur in people who are immobile and in those with a genetic predisposition to blood clotting. A thrombus can also form after damage occurs in an artery, vein, or surrounding tissue.
What are the main reasons of thrombus formation?
Causes of a thrombus in a vein (venous thrombosis) include:
- Injury to the leg veins.
- Illness that affects the veins.
- Immobility.
- Broken bone.
- Certain medications.
- Obesity.
- Inherited (genetic) disorders.
- Autoimmune disorders that increase the risk of blood clots.
