There's no hard-and-fast rule about when you should delete temporary files. If you want your computer in top operating condition, then it's recommended that you delete temporary files once they're no longer being used by an app. You can delete your system's temporary files as often as you feel comfortable doing so.
Can deleting temp files cause problems?
Reputable. Deleting temporary files shouldn't cause you any problems at all. Deleting registry entries can cause tons of trouble to the point where you have to reinstall your OS.
Is it good to delete temp files?
Programs often store temporary files on your hard drive. Over time, these files can start to take up a lot of space. If you are running low on hard drive space, clearing temporary files is a good way to reclaim additional disk storage space. ... All temporary files will now be deleted.