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Why Does Ceftriaxone Cause Biliary Sludging?

David Miller • • 6 min read
Why Does Ceftriaxone Cause Biliary Sludging?

The concentration of ionized calcium in the bile is elevated and ceftriaxone can precipitate with calcium, like what occurs with bilirubin, and so ceftriaxone-associated biliary sludge

biliary sludge
Biliary sludge is a mixture of particulate solids that have precipitated from bile. Such sediment consists of cholesterol crystals, calcium bilirubinate pigment, and other calcium salts. Sludge is usually detected on transabdominal ultrasonography.
is mainly composed of a calcium-ceftriaxone complex.

Can ceftriaxone cause biliary Pseudolithiasis?

Ceftriaxone-associated gallbladder pseudolithiasis is a not uncommon complication of this common antibiotic, where a ceftriaxone-calcium precipitate forms gallbladder sludge. It appears more common in pediatric patients.

Can ceftriaxone cause gallstones?

Ceftriaxone-induced gallstones are an uncommon but recognized complication of therapy with this antibiotic. Patients should be counseled regarding the possibility of this complication and informed to recognize and report biliary-type symptoms early during the course of treatment.

David Miller
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David Miller

David Miller brings 15 years of experience in global economics, personal finance strategy, and market dynamics. He specializes in turning complex economic trends into actionable insights for everyday readers.