Space Shuttle Challenger exploded just after take off on January 28, 1986. The Challenger disaster has been linked to unusually cold temperatures in the days leading up to take off. The Columbia disaster was not weather-related.

Have any spaceships exploded?

STS-107: Space Shuttle Columbia Disaster

Crew of the space shuttle Columbia (left to right): David Brown, Rick Husband, Laurel Clark, Kalpana Chawla, Michael Anderson, William McCool, and Ilan Ramon. The shuttle broke up catastrophically on February 1, 2003, killing all aboard.

How many spaceships have blown up in space?

During spaceflight. As of March 2021, in-flight accidents have killed 15 astronauts and 4 cosmonauts, in five separate incidents. Three of them had flown above the Kármán line (edge of space), and one was intended to do so.