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Why Is Alcohol Zero Order Kinetics?

Elena Rostova • • 6 min read
Why Is Alcohol Zero Order Kinetics?

Alcohol dehydrogenase (ADH) is located in the cytosol of stomach and liver cells and functions as the main enzyme for alcohol metabolism

alcohol metabolism
Ethanol, an alcohol found in nature and in alcoholic drinks, is metabolized through a complex catabolic metabolic pathway. In humans, several enzymes are involved in processing ethanol first into acetaldehyde and further into acetic acid and acetyl-CoA.
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(5). ... Therefore, the enzyme appears to show zero-order kinetics because once the enzyme is saturated, the reaction rate is no longer dictated by the concentration of the ethanol (3).

Is alcohol zero order kinetics?

The authors suggest that elimination of alcohol from blood is always linear with time, i.e., zero order kinetics. They also state that the process is mediated by enzymatic conversion.

Is alcohol eliminated by first-order kinetics?

Alcohol elimination followed first-order kinetics, in which the elimination rate is proportional to concentration, rather than zero order in which the metabolic rate is independent of concentration.

Elena Rostova
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Elena Rostova

Elena Rostova holds a Master's degree in Public Health Journalism. She covers groundbreaking medical research, holistic wellness trends, mental health awareness, and nutritional science.