The queen slime doesnt enrage. In fact, one of her stages makes her fly everywhere so she will eventually get out of the hallow.

When should I kill Queen slime?

Queen Slime can be killed easily before any other Hardmode bosses, and even before destroying Demon or Crimson Altars. The Crystal Assassin armor she drops will help the player survive in early Hardmode. Like most bosses, she is immune to lava, but her minions are not.

Does Royal gel work on Queen slime?

Royal Gel is an accessory obtained from the Treasure Bag dropped by King Slime in Expert Mode. ... King Slime and his Spiked Slimes, though the normal Blue Slimes that King Slime spawns remain docile. Queen Slime and her Bouncy Slimes, Crystal Slimes, and Heavenly Slimes.