When taken by mouth: Mastic is POSSIBLY SAFE for most people when taken appropriately for up to 3 months. It might cause nausea, diarrhea, or constipation in some people.

Does H. pylori cause constipation?

Recently, the gut microbiota has been implicated in the development of constipation. Helicobacter pylori infection is considered to be a possible factor influencing the gut microbiota profile. Here, we investigated the effect of H. pylori eradication therapy on symptoms of chronic constipation.

Should you take mastic gum on an empty stomach?

I immediately began taking one pill morning and night on an empty stomach (though this can cause stomach upset in some and they recommend easing into, first with one pill every other day, then one pill every day, then finally two a day. But it is very important to take it on an empty stomach.)