Cigarette smoking can cause coronary spasm and is a risk factor for vasospastic angina.

Does nicotine cause circulation problems?

Nicotine causes your blood vessels to constrict or narrow, which limits the amount of blood that flows to your organs. Over time, the constant constriction results in blood vessels that are stiff and less elastic. Constricted blood vessels decrease the amount of oxygen and nutrients your cells receive.

Does nicotine cause bronchospasm?

These results indicate that 1) nicotine is the primary causative agent responsible for the first-phase bronchoconstriction and 2) nonnicotine smoke particulates evoke the release of TxA2, PGD2, and PGF2 alpha, which act on TxA2 receptors on airway smooth muscles and induce the second-phase response to cigarette smoke.