Increase the Dose or Switch? In general, it takes approximately 4 to 6 weeks for antidepressants to work. If you are still experiencing symptoms after this amount of time, talk to your doctor.

How long does it take for SNRIs to work?

But people typically start noticing positive changes after about 4 to 6 weeks of treatment. It can take several months to feel the full effect of the medication. But if you're not feeling any improvements after about 6 to 8 weeks, talk to your doctor about trying another treatment or adjusting your dosage.

Why do SNRIs take so long to work?

Instead antidepressants target our DNA, in particular the genes that code for the serotonin transporter. They make these genes less active, so fewer serotonin transporter molecules are available in the brain. This, it is argued, explains the delayed action of antidepressants.