For example, too much mTOR activity is clearly connected to certain types of cancers and neurological diseases, particularly epilepsy and there's some evidence even for autism. Too little mTOR activity is connected to diseases such as atrophy of the muscle in certain situations, even aging a certain cell.

Does mTOR cause aging?

Accordingly, mTOR has been implicated in many of the processes that are associated with aging, including cellular senescence, immune responses, cell stem regulation, autophagy, mitochondrial function, and protein homeostasis (proteostasis) ^3,8–10.

Is it good to inhibit mTOR?

Inhibition of mTOR is a promising strategy for treatment of number of cancers. Limited clinical activity of selective mTORC1 agents have made them unlikely to have impact in cancer treatment. The development of competitive ATP-catalytic inhibitors have the ability to block both mTORC1 and mTORC2.