Grignard reagents are formed by the reaction of magnesium metal with alkyl or alkenyl halides. ... They're also very strong bases and will react with acidic hydrogens (such as alcohols, water, and carboxylic acids). Similar to or the same as: very similar to organolithium reagents.

Can Grignard reagents react with carboxylic acids?

1) Reactions of Grignard reagents with carboxylic acids. ... They add to ketones, aldehydes, esters (twice), acid halides (twice), epoxides, and a number of other carbonyl-containing compounds.

What can Grignard reagents not react with?

Grignard reagents do not typically react with organic halides, in contrast with their high reactivity with other main group halides. In the presence of metal catalysts, however, Grignard reagents participate in C-C coupling reactions.