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Where Does Loperamide Act?

Sarah Jenkins • • 2 min read
Where Does Loperamide Act?

CLINICAL PHARMACOLOGY
Mechanism of Action In vitro and animal studies show that IMODIUM® (loperamide hydrochloride) acts by slowing intestinal motility and by affecting water and electrolyte movement through the bowel. Loperamide binds to the opiate receptor in the gut wall.

What receptors does loperamide act?

Loperamide is an opioid receptor agonist and acts on the mu opioid receptors in the myenteric plexus large intestines; it does not affect the central nervous system like other opioids.

Does loperamide act centrally?

Loperamide (5.2. 35) (Imodium) is a long-acting synthetic antidiarrheal; it is peripherally acting μ-opioid receptor agonist that is not absorbed from the gut and has no effect on the adrenergic system or central nervous system but may antagonize histamine and interfere with acetylcholine.

Sarah Jenkins
Author

Sarah Jenkins

Sarah Jenkins is a veteran tech journalist with over 12 years of experience covering artificial intelligence, mobile innovations, and digital ethics. Her insights have appeared in leading technology publications worldwide.