The rate-limiting step of a chemical reaction is not concerned with how much energy is liberated or consumed. Instead, the rate-limiting step is defined as the slowest step out of all the steps that occur for a given chemical reaction.

What is rate-limiting step in bioavailability?

4. Rate Limiting Steps In Drug Absorption In a series of kinetic or rate processes, the rate at which the drug reaches the systemic circulation is determined by the slowest of various steps involved in the sequence. Such a step is called as the rate limiting step.

What is the meaning of rate-limiting step?

The slowest step in a metabolic pathway or series of chemical reactions, which determines the overall rate of the other reactions in the pathway. In an enzymatic reaction, the rate-limiting step is generally the stage that requires the greatest activation energy or the transition state of highest free energy.