Most antiepileptic drugs (AEDs) aim to reduce the excitability in neural tissue by reducing the excitability of individual neurons through selective ion channel blockers, enhancing inhibitory synaptic transmission or inhibiting excitatory synaptic transmission (11).

How do you reduce neuron excitability?

GABA (γ-aminobutyric acid) decreases neuronal excitability by activating GABA(A) channels that generate phasic and tonic currents. The level of tonic inhibition in neurons varies.

What do anticonvulsants do to the brain?

Anticonvulsants work by calming hyperactivity in the brain in various ways. For this reason, some of these drugs are used to treat epilepsy, prevent migraines, and treat other brain disorders.