(Review of the mechanism of action of lithium, its clinical uses and toxicity; states that prolonged exposure to high doses of lithium [above 2 mM] can cause liver injury).

Is lithium metabolized in the liver?

Lithium is not liver metabolized. It is excreted through kidney. The drug is not protein bound and 70- 80% reabsorbs proximal tubule of the kidney. Its level increase with decrease in serum level of sodium ion especially during dehydration, administration with thiazide diuretics.

What organs are affected by lithium?

The three organ systems that may be negatively affected by lithium are the thyroid gland, kidneys and parathyroid glands.