Aneuploidy originates during cell division when the chromosomes do not separate properly between the two cells (nondisjunction). Most cases of aneuploidy in the
How is aneuploidy caused?
Errors in chromosome segregation lead to aneuploidy, a state where the number of chromosomes in a cell or organism deviates from multiples of the haploid genome. Aneuploidy arising through chromosome mis-segregation during meiosis is a major cause of infertility and inherited birth defects.
What is the most common cause of aneuploidy?
Most Aneuploidies Arise from Errors in Meiosis, Especially in Maternal Meiosis I. For some time, researchers have known that most aneuploidies result from the nondisjunction of chromosomes during meiosis.
