Conclusions: Use of statins and ezetimibe was inversely correlated with severe hyponatremia. Consequently, these drugs are unlikely culprits in patients with hyponatremia, and they appear safe to initiate in hyponatremic patients.

Can statins cause low sodium levels?

Still, pending additional data in support of a protective effect from lipid-lowering drugs with regard to hyponatremia, the most prudent conclusion is perhaps that lipid lowering agents, statins and ezetimibe in particular, are unlikely to cause or contribute to severe hyponatremia.

What medication can cause low sodium levels?

Known offenders include acetazolamide, amiloride, amphotericin, aripiprazole, atovaquone, thiazide diuretics, amiodarone, basiliximab, angiotensin II receptor blockers, angiotensin-converting enzyme inhibitors, bromocriptine, carbamazepine, carboplatin, carvedilol, celecoxib, cyclophosphamide, clofibrate, desmopressin, ...