Piperidine is commonly manufactured by hydrogenation of pyridine over Pt, Pd or Raney-Ni catalyst in a liquid-phase reaction. Complete saturation of the pyridine ring can be achieved by nickel-aluminium alloy in 0.5 M KOH at rt with yields of 51–90%. The reduction with sodium and alcohol was also reported.

What drug has a piperidine ring?

Use in pharmaceutical drugs

Many pharmaceutical drugs contain a piperidine ring because the group tends to impart pharmacokinetics such as water solubility and bioavailability. Examples of drugs that contain piperidines include mesoridazine, thioridazine, haloperidol, droperidol, PCP, benperidol, and risperidone.

Is piperidine a drug?

Thioridazine is a piperidine antipsychotic drug that was previously widely used in the treatment of schizophrenia and psychosis. Due to concerns about cardiotoxicity and retinopathy at high doses, this drug is now prescribed less than previously and is mostly used for refractory cases.