If you are Rh negative, you have the ability to produce anti-D antibodies in your plasma. Both men and women with negative blood types (A-, B-, AB-, and O-) are Rh negative. Most people will need to periodically receive red blood cell immunizations to stimulate the production of anti-D antibodies.

Does plasma need to be Rh compatible?

ABO/RhD compatibility

The plasma used must be ABO-compatible with the recipient (Table II) (Grade of recommendation: 1C+)^3,4,50.

Does Rh factor matter in plasma transfusion?

Rh factor. Blood is either Rh-positive or Rh-negative, depending on whether the red blood cells have Rh antigens on their surface. ... This is because an Rh-positive blood transfusion can cause a person with Rh negative blood to make antibodies against the Rh factor, causing a transfusion reaction (discussed below).