Hypothesis proposed by Francis Crick in 1966 to explain the observed degeneracy in the third position of a codon.

Who proposed Wobble hypothesis?

To explain the possible cause of degeneracy of codons, in 1966, Francis Crick proposed “the Wobble hypothesis”.

What is the wobble theory?

A theory to explain the partial degeneracy of the genetic code due to the fact that some t-RNA molecules can recognize more than one codon. The theory proposes that the first two bases in the codon and anticodon will form complementary pairs in the normal antiparallel fashion.