First, the mesenchymal cells are commited to become cartilage cells. This committment is caused by paracrine factors that induce the nearby mesodermal cells to express two transcription factors, Pax1 and Scleraxis.

What cells appear first in osteogenesis?

First, the mesenchymal cells are commited to become cartilage cells. This committment is caused by paracrine factors that induce the nearby mesodermal cells to express two transcription factors, Pax1 and Scleraxis.

What is the process of osteogenesis?

Osteogenesis/ossification is the process in which new layers of bone tissue are placed by osteoblasts. ... Endochondral bone formation occurs when hyaline cartilage is used as a precursor to bone formation, then bone replaces hyaline cartilage, forms and grows all other bones, occurs during development and throughout life.