Genetic contribution seems to play a major role in GERD and GERD- related disorders development such Barrett's esophagus and esophageal adenocarcinoma. Twin and family studies have revealed an about 31% heritability of the disease.

Are esophagus issues genetic?

Risk Factors for Esophageal Diseases

The majority of cases of Barrett's esophagus and esophageal cancer are not believed to be caused by genetic factors, the researchers write. The most common risk factors are age, smoking, heavy drinking, and being male. Men are much more likely to develop cancer of the esophagus.

Does Barrett's esophagus run in families?

Barrett esophagus usually occurs sporadically in people with no family history of the condition. In rare cases, it can affect more than one family member; however, it is unclear whether these cases are due to common environmental exposures or an inherited predisposition (or a combination of the two).