Then he cheats on Addison again when they make an effort to repair their relationship. He and Meredith make out at the hospital prom. When Meredith and Derek are figuring out their relationship in season four, Derek kisses Rose. Finally, Derek lets one of his interns in DC kiss him when he’s married to Meredith.

Is Rose pregnant with Derek’s baby?

“I wish there were a good way to say this: ‘I’m carrying your child,’ ” Rose tells Derek, whose stunned look might match that worn by “Grey’s” fans. Adding to the mystery: In an ABC podcast in May, Rhimes said Rose isn’t pregnant, and was later quoted as saying she wouldn’t deceive “Grey’s” loyalists.

Who does Derek end up with in the end?

In the season finale, they decide to give their planned wedding to Alex and Izzie. Due to their tight schedule, they instead informally marry, and Derek writes down their “vows” on a post-it note. They legalize their marriage in season seven in order to adopt Zola, a young African orphan treated for spina bifida.

Meredith and Derek end up back together but then break up when Meredith can’t commit. They continue having sex until Derek starts dating a nurse, Rose. Meredith and Derek realize they belong together after working closely together and finally succeeding with a clinical trial.