Taken together, there remains the possibility that creatine can increase risk of mania or depression in susceptible individuals. It is also possible that long-term high dosing of creatine alters creatine transporter function or creatine kinase activity in a manner that adversely affects emotional regulation.

Is creatine good for mental health?

The study shows that increased creatine intake results in improved brain function, similar to effects shown previously in muscle and heart. The results agree with previous observations showing that brain creatine levels correlate with improved recognition memory and reduce mental fatigue.

Does creatine make anxiety worse?

Although most healthy people can take it with no problem, creatine can, in rare cases, have adverse effects, particularly when used in excess. Side effects can include: Weight gain. Anxiety.

Side effects of creatine include:
abdominal pain.abnormal heart rhythm (arrhythmias)cardiac arrest.heart disease (cardiomyopathy)dehydration.diarrhea.high blood pressure (hypertension)ischemic stroke.