In a case series of 49 patients, 76% of strokes that were linked temporally to a presentation of mania presented in the first month following stroke.

Can a stroke cause a manic episode?

Temporal or causal relationship = there is evidence from historical data, physical examination, or laboratory findings that manic symptoms are a direct physiological consequence of a stroke, occurring immediately or up to 3 years thereafter.

Can a stroke make someone bipolar?

The onset of bipolar disorder (BD) secondary to a stroke event is a rare clinical entity. Although it may be related to specific regions of the brain, several other factors have been linked to its expression such as subcortical atrophy or chronic vascular burden.