Interestingly, a single flumazenil dose can reverse the anticonvulsant tolerance after chronic benzodiazepine exposure.

What happens with benzodiazepine tolerance?

For people who have anxiety disorders or struggle with insomnia, studies have shown that some of the sedative, muscle relaxant, and sleep-promoting effects of benzodiazepines are diminished as tolerance develops.

Is benzodiazepine memory loss permanent?

But when benzodiazepines are consumed for long periods of time, they can actually harm the brain. Taking benzodiazepines recreationally or in larger doses than prescribed can cause mental confusion, memory issues, permanent brain changes, and an increased risk of Alzheimer's disease and dementia.