Thyroid hormones increase the expression of LDL receptors on the hepatocytes,⁷⁴ and increase the activity of lipid‐lowering liver enzymes, resulting in a reduction in low‐density lipoprotein levels.

Can thyroid problems cause liver problems?

When thyroid hormone levels are very high in hyperthyroidism, blood liver function tests can be also be increased to levels that suggest damage to the liver, even though severe liver problems from hyperthyroidism is extremely rare.

Can an underactive thyroid affect your liver?

Research published in the Journal of Gastroenterology and Hepatology suggested that not only does the liver play a role in the chemical process that develops thyroid hormones, but untreated hypothyroidism can cause problems in liver function over time.