Shisui committed suicide by jumping into the Naka River, while giving Itachi his final eye.

Can Shisui be still alive?

No. he committed suicide because he didn't want Danzo to take his other sharingan, so before he died he gave the sharingan to itachi, and itachi gave it to one of his crows, and then Shisui committed suicide. Originally Answered: Is there any chance that Shisui is alive?

Does Shisui appear in Boruto?

Shisui Uchiha has a new home. The ninja found his way into Naruto to Boruto: Shinobi Striker. The DLC is immediately available on November 24, 2020, though at the time of writing only the PlayStation Store product page was online.