GAPDH is a 146 kDa tetramer composed of four 30-40 kDa subunits.

What is molecular weight of GAPDH?

Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) is a ubiquitous enzyme involved in glycolysis, converting glyceraldehyde-3-phosphate into 1,3 diphosphoglycerate. This constitutively expressed, homotetramer protein can be found in the nucleus and cytoplasm, and the monomer has a theoretical molecular weight of 36 kDa.

What is the purpose of GAPDH mRNA?

GAPDH is a moonlighting protein that functions as a glycolytic enzyme as well as a uracil DNA glycosylase. Results indicate that CIB1 is uniquely positioned to regulate PI3K/AKT and MEK/ERK signaling and that simultaneous disruption of these pathways synergistically induces a nuclear GAPDH-dependent cell death.