Aminoglycosides bind to the bacterial 30s ribosomal subunit and inhibit bacterial protein synthesis, which explains the efficacy of these antibiotics on rapidly growing bacteria. The transport of aminoglycosides into cells is concentration dependent and uses a specific carrier.

What is the mechanism of action of aminoglycosides?

Aminoglycosides are potent bactericidal antibiotics that act by inhibiting bacterial protein synthesis, thereby binding bacterial 30S or 50S ribosomal subunit, inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site, and also causing misreading of mRNA.

What do aminoglycosides do?

Aminoglycosides are potent bactericidal antibiotics that act by creating fissures in the outer membrane of the bacterial cell. They are particularly active against aerobic, gram-negative bacteria and act synergistically against certain gram-positive organisms.