Besides the liver, the kidney is the only organ capable of generating sufficient glucose (gluconeogenesis) to release into the circulation, and it is also responsible for filtration and subsequent reabsorption or excretion of glucose.

Does the kidney produce glycogen?

Renal gluconeogenesis The normal human kidney contains negligible amounts of glycogen and kidney cells other than proximal tubules, that could theoretically store glucose, lack glucose-6-phosphatase. Thus, essentially all renal glu- cose release is probably due to gluconeogenesis.

How does kidney process glucose?

Under normal circumstances, up to 180 g/day of glucose is filtered by the renal glomerulus and virtually all of it is subsequently reabsorbed in the proximal convoluted tubule. This reabsorption is effected by two sodium-dependent glucose cotransporter (SGLT) proteins.