Both sympathetic and parasympathetic preganglionic neurons are cholinergic, meaning they release acetylcholine (Ach) at the synapse in the ganglion. In the parasympathetic system, postganglionic neurons are also cholinergic.

Where in a neuron is acetylcholine released from?

Acetylcholine in the Peripheral Nervous System At the presynaptic terminal, acetylcholine storage occurs within the presynaptic vesicle. With the stimulation of the presynaptic terminal, acetylcholine is released from the vesicles and into the synaptic cleft, where the neurotransmitter is free to bind with receptors.

Do all neurons secrete acetylcholine?

All preganglionic neurons secrete acetylcholine (Ach) which binds nicotinic receptors on the surface of the postganglionic neurons.