Large platelets can be seen when platelet turnover is increased (as in immune thrombocytopenic purpura). They may also be present in myeloproliferative neoplasms, myelodysplasia, and some congenital thrombocytopenia syndromes, including Bernard-Soulier syndrome and MYH9-related disorders.

Are large platelets bad?

However, individuals with large platelets may have an increased risk for thrombotic complications because some genetic traits share an association with an increased MPV and a higher risk for cardiovascular disease.

Are large platelets immature?

Immature platelets or reticulated platelets are newly released thrombocytes. They can be identified by their large size and high RNA cytoplasm concentration.