Yes, thyroid disease can affect your mood — primarily causing either anxiety or depression. Generally, the more severe the thyroid disease, the more severe the mood changes. If you have an overactive thyroid (hyperthyroidism), you may experience: Unusual nervousness.

Can thyroid issues cause altered mental status?

If not adequately treated, thyrotoxicosis can lead to serious complications including delirium, altered mental status, osteoporosis, muscle weakness, atrial fibrillation, congestive heart failure (CHF), thromboembolic disease, cardiovascular collapse, and death [2].

Can thyroid problems mimic bipolar disorder?

Both thyroid dysfunction and antithyroid antibodies have been widely reported to be associated with affective disorders. Cross-sectional [1, 2] or cohort studies [3, 4] have found that hypothyroidism increased risk of developing depression or bipolar disorder.