Treatment with VELCADE can cause or worsen heart rhythm problems and heart failure. Your doctor may closely monitor you if you have, or are at risk for, heart disease. Tell your doctor if you experience chest pressure or pain, palpitations, swelling of your ankles or feet, or shortness of breath.

Does multiple myeloma affect the heart?

Multiple myeloma puts you at risk for heart and lung problems, including blood clots, pulmonary hypertension, heart failure, and irregular heartbeat (arrhythmias) among other problems. Your risk for these problems is greater if you already have high blood pressure, type 2 diabetes, or high cholesterol.

Is Velcade a strong chemotherapy drug?

by Drugs.com Velcade is not a traditional form of chemotherapy (chemo). Velcade is a targeted drug therapy in the class of drugs known as proteasome inhibitors.