Procainamide is given IV or PO with the onset of action in 10 to 30 minutes. The loading dose is of IV procainamide is 10 to 17 mg/kg and administered at a rate of 20 to 50 mg/min. Alternatively, this may be dosed at 100 mg every 5 minutes in adult patients.

When is procainamide given?

Immediate-acting procainamide usually is taken every 3 or 4 hours. The long-acting product is usually taken every 6 or 12 hours.

How do you make a procainamide infusion?

Intravenous Administration Each 100 mg of procainamide must be diluted in 10 ml of sterile water for injection or D5W injection. Inject by slow IV push at a rate not to exceed 50 mg/minute. Intravenous infusion: NOTE: According to the manufacturer, procainamide injection is compatible in D5W.