The rash looks like red bumps that gradually fill with a milky fluid. The fluid-filled bumps are all in the same stage at the same time, compared to chickenpox, where the skin blisters are in different stages of appearance with a mix of blisters, bumps, and crusted lesions at a given time.

What does the smallpox rash look like?

After 2 to 3 days of illness, a flat, red rash appears. It usually starts on the face and upper arms, and then it spreads all over your body. Over the next 2 to 3 weeks, the flat, red spots become firm and dome-shaped and fill with pus. Then they scab over.

Does smallpox still exist?

The last naturally occurring case of smallpox was reported in 1977. In 1980, the World Health Organization declared that smallpox had been eradicated. Currently, there is no evidence of naturally occurring smallpox transmission anywhere in the world.