Interval between treatments and courses: “The half-life of rituximab is about 1 week; median duration of persistence in the blood at active levels is of about 3 months: ….

How long does immunosuppression from rituximab last?

Complete B cell-depletion for up to 48 weeks can be observed after a single dose of rituximab (5).

How many times can rituximab be given?

Administer RITUXAN as a single-agent every 8 weeks for 12 doses. Following completion of 6-8 cycles of CVP chemotherapy, administer once weekly for 4 doses at 6-month intervals to a maximum of 16 doses.