Etanercept has been linked to rare instances of acute, clinically apparent liver injury.

Does Enbrel cause elevated liver enzymes?

After researchers controlled for the effects of other factors, the risk of elevated or abnormal liver enzyme levels was 58% higher in 1,449 patients on infliximab (Remicade) and 35% higher in 849 patients on adalimumab (Humira), but no different in 1,383 patients on etanercept (Enbrel), compared with 4,147 patients on …

What is the most commonly reported side effect of Enbrel?

Injection-site reactions is one of the most commonly reported side effects of Enbrel. These may include: redness or discoloration. itching.