Epidemiological evidence and intervention studies clearly show that in humans saturated fat significantly worsen insulin-resistance, while monounsaturated and polyunsaturated fatty acids improve it through modifications in the composition of cell membranes which reflect at least in part dietary fat composition.

Does saturated fat raise blood sugar?

Along with protein and carbohydrates, fat is one of the main macronutrients. Unlike carbohydrate, and to a small extent protein, the fat we eat does not directly raise our blood sugar levels, whether we have diabetes or not.

How does saturated fat increase insulin resistance?

Saturated fatty acids decrease responsiveness of the cell membrane to insulin-mediated actions through a decrease in binding affinity, which contributes to increased insulin resistance (28). High protein intake, especially from animal-based sources, has been associated with an increase in type 2 diabetes risk (29–31).