The leukotrienes play a major role in the inflammatory response to injury; they have been implicated in the pathogenesis of several inflammatory diseases, most notably asthma, psoriasis, rheumatoid arthritis, and inflammatory bowel disease.

Do Leukotrienes cause inflammation?

Leukotrienes are inflammatory chemicals the body releases after coming in contact with an allergen or allergy trigger. Leukotrienes cause tightening of airway muscles and the production of excess mucus and fluid.

What is the difference between leukotrienes and histamine?

Histamine is stored in intracellular granules of basophils and is released following cell stimulation. In contrast to histamine, no leukotrienes (LTs) are stored in the cells because LTs are produced from arachi- donic acid by 5-lipoxygenase following IgE-dependent stimulation.