Calcium ions (Ca2+) play a major role in the tight regulation of coagulation cascade that is paramount in the maintenance of hemostasis1,2. Other than platelet activation, calcium ions are responsible for complete activation of several coagulation factors, including coagulation Factor XIII (FXIII)3.

How does calcium cause coagulation?

Calcium binds to the phospholipids that appear secondary to the platelet activation and provides a surface for assembly of various coagulation factors.

Does calcium play a role in nerve conduction?

In neurons, calcium is the ultimate multitasker. It helps propagate electrical signals down axons. It triggers synaptic terminals to dump their cargo of neurotransmitters into synapses.