SNRI antidepressants, including duloxetine, may increase the risk of bleeding events. Combined use of aspirin, nonsteroidal anti-inflammatory drugs (e.g., ibuprofen, naproxen), warfarin, and other anti-coagulants may increase this risk.

Does duloxetine cause blood thinning?

Cymbalta (duloxetine) can increase the risk of bleeding or bruising, especially if you’re also taking aspirin, NSAIDs (like Advil), or blood thinners. The bleeding can be life-threatening.

Do SNRIs increase risk of bleeding?

There are several potential mechanisms by which SSRIs and SNRIs may increase bleeding. These include direct platelet effects, such as the antagonism of serotonin transporters, thereby impairing platelet aggregation;14 depletion of platelet serotonin levels;3, 5, 11, 15, 16 and reduction in platelet count.